Abstract
| Grant Number: | 5R42NS046997-04 |
| Project Title: | Novel CSF biomarker to predict impaired cognition in HIV |
Abstract:
DESCRIPTION (provided by applicant): The focus of this project is to explore the relationship between inflammatory cells and cognitive dysfunction in populations with HIV-1 infection. Extensive work has found that a biomarker is detected in lumbar cerebrospinal fluid of HIV(+) subjects with impaired cognition. Presently there are no suitable clinical tests to identify early neuro-inflammatory injury to neurons in such disorders as HIV-1 dementia. The ability to identify and treat HIV(+) populations before the onset of irreversible brain damage is highly desirable and forms the basis for this STTR proposal.
Thesaurus Terms:
AIDS /HIV neuropathy, biomarker, cerebrospinal fluid, cognition disorder, diagnosis design /evaluation, neurotoxin, technology /technique development
AIDS dementia complex, cognition, diagnostic test, early diagnosis, health related legal, mental disorder diagnosis, nervous system disorder diagnosis, neural information processing, neuropathology, neuropsychological test, synapse, tissue /cell culture
clinical research, human subject, laboratory rat, patient oriented research
| Institution: | INFLAME THERAPEUTICS, INC. |
| 8080 NORTH STADIUM DRIVE |
| HOUSTON, TX 77054 |
| Fiscal Year: | 2006 |
| Department: | |
| Project Start: | 15-FEB-2004 |
| Project End: | 31-JUL-2008 |
| ICD: | NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE |
| IRG: | ZRG1 |
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