Abstract
| Grant Number: | 5R44AG018694-03 |
| Project Title: | New Method of SNP Typing in Aging Related Disorders |
Abstract:
DESCRIPTION (provided by applicant): The objectives of this proposal is to
commercialize a novel assay we have developed in our phase I research for the
detection of genetic variants (SNPs) that may be linked to aging related
disorders such as Alzheimer's disease, breast cancer and cardiovascular
disease. The specific aims are the further development of this economical and
ultra-sensitive platform for identification of single nucleotide polymorphisms
(SNPs). This new approach will eliminate the typical requirement for a PCR
amplification step in SNP assays, and therefore will be ideally suited for
ultra-high throughput screening of large populations.
The assay is based on the use of an oligonucleotide ligation assay (OLA), a DNA
microarray, and our novel reporter label (PRP) that allows for ultrasensitive
detection of DNA.
We expect that the completion of our SBIR program will result in the
commercialization of SNP identification using kits, protocols, and reagents for
population screening and pharmacogenomics for sale to both the research and
clinical biomedical communities.
PROPOSED COMMERCIAL APPLICATION:
The sale of kits and reagents that will become the preferred methodology for the screening of human populations for SNPs associated with specific age related diseases, such as Alzheimer's, breast cancer, and cardiovascular deterioration. The design of inexpensive user-friendly instrumentation suitable for individual medical practioners, clinical screening laboratories, and research facilities.
Thesaurus Terms:
aging, gene mutation, genetic screening, method development, microarray technology, single nucleotide polymorphism
Alzheimer's disease, breast neoplasm, cardiovascular disorder, genotype, reporter gene
biotechnology, nucleic acid hybridization
| Institution: | SEASHELL TECHNOLOGY, LLC |
| 3252 HOLIDAY CT, STE 115 |
| LA JOLLA, CA 920371808 |
| Fiscal Year: | 2003 |
| Department: | |
| Project Start: | 01-SEP-2000 |
| Project End: | 29-FEB-2008 |
| ICD: | NATIONAL INSTITUTE ON AGING |
| IRG: | ZRG1 |
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