PROTEIN STRUCTURE PROBLEM

• PROBLEM: LOCATE TRANSMEMBRANE SEGMENTS

OF BACTERIORHODOPSIN

• TM PROTEINS CROSS CELL WALLS SEVERAL TIMES

• SHORT LOOPS ON EITHER SIDE OF THE MEMBRANE

• GOAL: IDENTIFY SEGMENTS THAT ARE WITHIN

THE MEMBRANE, THE TRANSMEMBRANE DOMAINS

• OBJECTIVE: EVOLVE A COMPUTER PROGRAM

FOR PREDICTING WHETHER OR NOT A GIVEN

SEGMENT LIES IN TM DOMAIN

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