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IEEE Virginia Mountain Section

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Meeting: Thursday, January 18, 2018
at Hampton Inn – Downtown Roanoke


Digital Dysmorphology for Diverse Populations
with Genetic Syndromes

by Dr Marius George Linguraru

Abstract:: Genetic syndromes are the most common causes of cognitive impairment. Each year, nearly one million children ar e born with a genetic condition. These children experience a high incidence of serious medical complications and intellectual disability that require immediate treatment. Genetic conditions often present clinically with universally recognizable signs and symptoms, including recurring patterns of malformations on the face and body that are pathogenetically related. These patterns can be obvious or very subtle and manifest differently with age and ethnical background. However, quantitative facial measurements are not available to primary care physicians, pediatricians and neonatologist, nor are they performed in a standardized and reproducible fashion by geneticists. Delayed and erroneous diagnoses can cause significant suffering, irreversible injury, and even death.

The talk will present recent advancements in quantitative imaging, shape modeling and digital facial analysis to detect dysmorphology with a focus on computational modeling methods that integrate anatomical and imaging priors for the study of the variability of human anatomy. Developed at the Sheikh Zayed Institute for Pediatric Surgical Innovation at Children’s National Health Center, mGene is a non-invasive, smart phone application that identifies a wide array of genetic syndromes. The technology detects specific, clinically-proven markers of these disorders using objective and quantitative evaluation enhanced by machine learning. Working with the NIH National Human Genome Research Institute, we demonstrated widespread potential applicability of digital dysmorphology to diverse populations with genetic conditions with distinctive dysmorphic features. mGene promises to make sophisticated genetic expertise accessible in areas without specialized genetic clinics, typically unavailable in community hospitals and the developing world.

Speaker's Bio:: Marius George Linguraru, DPhil loves working with multidisciplinary teams of clinicians, scientists and engineers to help children grow healthy and happy. He is Principal Investigator in the Sheikh Zayed Institute for Pediatric Surgical Innovation at Children's National Health System, and Associate Professor of Radiology and Pediatrics at the School of Medicine and Health Sciences of George Washington University in Washington, DC. At the Sheikh Zayed Institute, Dr. Linguraru founded and directs the Quantitative Imaging Group that is creating the next paradigms in healthcare through image analysis and software-based technology that is objective, robust and widely accessible. He joined the Sheikh Zayed Institute from the National Institutes of Health Clinical Center, where he maintains an appointment as Associate Investigator. Dr. Linguraru is the Chair of the Technical Committee for Biomedical Imaging and Image Processing and a Distinguished Lecturer of the IEEE Engineering in Medicine and Biology Society. He is the recipient of numerous awards, including a prize for Excellence in Engineering by a Younger Engineer at the Houses of Parliament in London, UK. He completed his doctorate at the University of Oxford and holds masters’ degrees in science and in arts from the University of Sibiu, Romania. He held fellowships at the French National Institute of Research in Informatics and Mathematics and at Harvard University.

Meeting Details:
Thursday, January 18, 2018
Social:   7:00 PM

Presentation:  7:15 - 8:30 PM


Hampton Inn – Downtown Roanoke
27 Church Street SE
Roanoke VA 24011

Directions to Hampton Inn - Downtown Roanoke:

From I-581 take Exit 5 & keep LEFT towards Downtown/Williamson Road. In 0.4 miles Turn RIGHT onto Church Ave. Continue 500 ft to the Hampton Inn - Down Town Roanoke, on the LEFT.

Reservations:  Reservations: Please RSVP by End of Day (EOD), Monday January 15, if possible. Please specify the number of attendees. Please RSVP to Andrew Tribbett, Sec/Treas, at

Credit: • One continuing education credit will be awarded for attending this presentation..

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Congratulations to recipients of VMS Awards at the December meeting:
  • IEEE Outstanding Engineer of the Year - Branden Ring
  • IEEE Outstanding Service Award - Joe Hartwell
  • IEEE Educator of the Year Award - David Livingston
  • Joel Donahue Memorial Award - Joe Novak
  • David Geer Memorial Award for Engineering Excellence - Bud Jones
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Virginia Mountain Section Officers for 2017~2018

ChairmanGeorge Williams
Vice ChairmanObum Osineme
Secretary/TreasurerAndrew Tribbett
Member-at-LargeJohn K John
Member-at-LargeA. K. Briele
Member-at-LargeCy Harbourt
Member-at-LargeAndrew Pouche
Past ChairmanJoe Hartwell

The Virginia Mountain Section (VMS) of the IEEE has been serving members in the Southwest corner of the Commonwealth of Virginia since 1949.

We currently have two Student Branches in local universities and colleges:

  • Virginia Military Institute
  • Virginia Tech
and the VMS Consultants Network Affinity Group.

The purpose of this Affinity Group is to share information concerning consulting opportunities, and to make a list of consultants and their areas of expertise available to potential employers.

Anyone wishing to be added to this group, or desiring more information should contact David Livingston,

Information about our Section, the Chapters, and material of interest to our members may be found by selecting items in the left column of this page.

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(last modified: Jan 8, 2018 )