Meeting: Thursday, January 18, 2018at Hampton Inn – Downtown Roanoke
Digital Dysmorphology for Diverse Populationswith Genetic Syndromes
by Dr Marius George Linguraru
Abstract:: Genetic syndromes are the most common causes of cognitive impairment. Each year, nearly one million children ar
e born with a genetic condition. These children experience a high incidence of serious medical complications and intellectual disability that require immediate treatment.
Genetic conditions often present clinically with universally recognizable signs and symptoms, including recurring patterns of malformations on the face and body that are
pathogenetically related. These patterns can be obvious or very subtle and manifest differently with age and ethnical background. However, quantitative facial measurements
are not available to primary care physicians, pediatricians and neonatologist, nor are they performed in a standardized and reproducible fashion by geneticists. Delayed and
erroneous diagnoses can cause significant suffering, irreversible injury, and even death.
The talk will present recent advancements in quantitative imaging, shape modeling and digital facial analysis to detect dysmorphology with a focus on
computational modeling methods that integrate anatomical and imaging priors for the study of the variability of human anatomy. Developed at the Sheikh Zayed Institute for
Pediatric Surgical Innovation at Children’s National Health Center, mGene is a non-invasive, smart phone application that identifies a wide array of genetic syndromes. The
technology detects specific, clinically-proven markers of these disorders using objective and quantitative evaluation enhanced by machine learning. Working with the NIH National
Human Genome Research Institute, we demonstrated widespread potential applicability of digital dysmorphology to diverse populations with genetic conditions with distinctive
dysmorphic features. mGene promises to make sophisticated genetic expertise accessible in areas without specialized genetic clinics, typically unavailable in community hospitals
and the developing world.
Speaker's Bio:: Marius George Linguraru, DPhil loves working with multidisciplinary teams of clinicians, scientists and engineers
to help children grow healthy and happy. He is Principal Investigator in the Sheikh Zayed Institute for Pediatric Surgical Innovation at Children's National Health System, and
Associate Professor of Radiology and Pediatrics at the School of Medicine and Health Sciences of George Washington University in Washington, DC. At the Sheikh Zayed Institute,
Dr. Linguraru founded and directs the Quantitative Imaging Group that is creating the next paradigms in healthcare through image analysis and software-based technology that is
objective, robust and widely accessible. He joined the Sheikh Zayed Institute from the National Institutes of Health Clinical Center, where he maintains an appointment as
Associate Investigator. Dr. Linguraru is the Chair of the Technical Committee for Biomedical Imaging and Image Processing and a Distinguished Lecturer of the IEEE Engineering
in Medicine and Biology Society. He is the recipient of numerous awards, including a prize for Excellence in Engineering by a Younger Engineer at the Houses of Parliament in
London, UK. He completed his doctorate at the University of Oxford and holds masters’ degrees in science and in arts from the University of Sibiu, Romania. He held fellowships
at the French National Institute of Research in Informatics and Mathematics and at Harvard University.
Thursday, January 18, 2018
Social: 7:00 PM
Dinner: NOT INCLUDED WITH THIS PRESENTATION
Presentation: 7:15 - 8:30 PM
Members and Guests: NO COST FOR THIS PRESENTATION
Hampton Inn – Downtown Roanoke
27 Church Street SE
Roanoke VA 24011
Directions to Hampton Inn - Downtown Roanoke:
From I-581 take Exit 5 & keep LEFT towards Downtown/Williamson Road. In 0.4 miles Turn RIGHT onto Church Ave. Continue 500 ft to the Hampton Inn - Down Town Roanoke, on the LEFT.
Please RSVP by End of Day (EOD), Monday January 15, if possible. Please specify the number of attendees. Please RSVP to Andrew Tribbett, Sec/Treas, at A.S.Tribbett@ieee.org.
Credit: • One continuing education credit will be awarded for attending this presentation..
Virginia Mountain Section (VMS) of the IEEE has been serving
members in the Southwest corner of the Commonwealth of Virginia
currently have two Student Branches in local universities
the VMS Consultants Network Affinity Group.
The purpose of this Affinity Group is to share information concerning
consulting opportunities, and to make a list of consultants
and their areas of expertise available to potential employers.
Anyone wishing to be added to this group, or desiring more information
should contact David Livingston, firstname.lastname@example.org.
about our Section, the Chapters, and material of interest
to our members may be found by selecting items in the left
column of this page.