Keynote Speakers
Biography
Ahmed M. Al-Jumaily, is currently a Professor of Biomechanical Engineering and the Founder and Director of the Institute of Biomedical Technologies at the Auckland University of Technology, Auckland, New Zealand. He holds a PhD and M.Sc. from the Ohio State University, USA and a B.Sc. from the University of Baghdad. He is a FELLOW member of the American Society of Mechanical Engineering (ASME) and the Acoustical Society of America; in addition a member of 11 more international professional societies. He is the Editor of the ASME Journal of Engineering and Science in Medical Diagnostics and Therapy, the Editor for the ASME monograph series-Biomedical and Nanomedical Technologies and has been on the editorial and refereeing boards for several international journals. He has published more than 340 papers in international journals and conference proceedings including two ASME books on Vibration and Acoustics in Biomedical Applications and a third one on CPAP devices. He has supervised more than 90 postgraduate students from 34 countries in biomedical applications, vibrations, biomechanics, and electroactive polymers. During his academic career, he has forged strong alliances between academia and industries; in particular, in the medical devices area, which has resulted in many successful grants and contracts with companies and research organizations. Al-Jumaily’s current research focuses on biomedical applications, particular interest in the application of vibration and acoustics to airways constriction therapies and artery non-invasive diagnostics.
Title: Triggering Physiological Micro/Nano Mechatronics for Respiratory Treatments
Abstract
Micro and nanomechatronics in physiology include basic manmade applications in robotics, sensors, actuators, semiconductor materials and devices for various health diagnostics, treatments and therapy. However, since the first creation, such natural physiological systems have been the main constituents of driving various activities within living-being bodies. One of these nanomechatronics system is the airway smooth muscles (ASM) actomyosin cross-bridge cycling mechanism, which is the main driving force for airway constrictions in asthmatic attacks. It consists of an electrical stimulation triggering chemical activation followed by mechanical attachment/detachment between myosin and actin. This leads to lumen contraction and then respiratory bronchoconstriction. Various mechanisms in different parts of the lung can generate breathing difficulties. While excessive airway narrowing due to ASM hyperconstriction is a major symptom in many respiratory diseases including asthma, upper airway collapse is the main contributor to Obstructive Sleep Apnea (OSA) symptoms. Can external disturbance induced by superimposed pressure oscillation (SIPO) trigger those physiological mechanisms for lung treatments? A series of in vitro experiments and in vivo trials have demonstrated that both tidal and superimposed length oscillations reduce the active force in contracted ASM (healthy and asthmatics) for a relatively long term and that the latter enhances the force reduction of the former. Further, computational and experimental modellings including clinical trials have demonstrated that SIPO can modulate the upper airway and help to reduce the apnea index in a few OSA patients. This presentation demonstrates that SIPO does trigger lung therapy technologies to improve lung compliance and inflammatory stresses, preserve surfactant function and relax contracted ASM.
Dr. Mazlan is the co-founder and CEO of FAVORIOT Sdn Bhd. He is ranked Top 10 in IoT Top 100 Influencers by Postscapes 2017 & 2018, ranked Top 20 Global Thought Leaders on the Internet of Things (February 2019) by Thinkers360, ranked No. 20th Thought Leader in IOT by 2014 Onalytics Report - The Internet of Things - Top 100 Thought Leaders, ranked among 50 Most Impactful Smart Cities Leaders by World CSR Congress 2017 and UTM Alumni Industry Personality 2016. He is currently one of Global Vision Board Member (2017). Before Favoriot, he spent 2.5 years as CEO of REDtone IOT and 8 years in MIMOS Berhad as Senior Director Wireless Communications Cluster. He also spent 13 years in CELCOM (mobile operator), handling many senior management positions. Prior to Celcom, he spent 10 years as an Assoc. Professor at Universiti Teknologi Malaysia. He is currently the Adjunct Professor for Universiti Malaysia (UniMY) and Universiti Teknologi Petronas (UTP). He was also the Adjunct Professor for UTM from 2008 to 2013, UTHM (2004-2005, 2013-2016) and UniSZA (2017). Dr.Mazlan is a frequent speaker in many major & established IOT, Smart Cities and telco conferences locally and globally. He sits in Industry Advisory Panel (IAP) for several local universities. He graduated from Universiti Teknologi Malaysia with a BEE (1984), University of Essex (UK) with MSc. in Telematics (1986) and Universiti Teknologi Malaysia with a PhD in Telecommunications (1993). He also received an Honorary Doctorate in Electrical Engineering from UTHM (2017).